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Re: ORGLIST: amine extraction

From: Ken Knott <kknott>
Subject: Re: ORGLIST: amine extraction
Date: Fri, 25 May 2012 11:13:30 -0400
Yeah, standard DMF extraction is aqueous washes with satd. LiBr solution or something like that...  

On Fri, May 25, 2012 at 10:57 AM, Petr Melsa <melsap> wrote:
Try to dissolve you compound in diethyl ether of ethyl acetate and wash with 5% aq. lithium chloride a couple of times.

Good luck,

Petr

On Fri, May 25, 2012 at 3:38 PM, Ilya Avrutov <IAvrutov> wrote:
W=Hi Thanu,

What else your compound soluble in? If it soluble in some
water-immiscible solvents, you could try to saturate aqueous solution
with NaOH and extract the produt in another solvent. I think DMF will
remain in aqueous layer mostly.

Best,
Ilya

-----Original Message-----
From: orglist-everybody
[mailto:orglist-everybody] On Behalf Of thanu
Sent: Friday, May 25, 2012 8:44 AM
To: OrgList
Subject: ORGLIST: amine extraction

Hi all,

I have prepared a moity which has pyridine and a secondary amine in it
by substitution reaction. The reaction was done using DMF, the issue is
I tried workup using acid-base method but was not able to remove DMF
fully. Also i cant use high vaccum coz the compound has a low boiling
point. Can anyone suggest a method to remove DMF at low temperatures? My
compound is soluble in cold water too and the reaction was done in THF
which didnot work. Hiope for better solutions from any of u.

Thanks n regards,
Thanu



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